When QuickBooks doesn't start correctly because of improper settings or a third-party application's communication problems, the error QuickBooks Error 80040408 appears. Usually, automated processes are when this issue occurs.  Make sure QuickBooks is set up correctly and that the program that calls it has the right permissions and settings in order to resolve the issue. Give 1.855.738.2784 a call if you need expert guidance and help with QuickBooks.